Contact Information:

 Department of Chemistry

 Office: CIS E305

 Email:  r-ismagilov@uchicago.edu

 Voice: 773 702 5816

 Fax:    773 834 3544

 Mailing Address: 929 East 57th Street,

 Chicago, IL 60637 Directions

POSTDOCTORAL POSITIONS AVAILABLE

Recent Publications:

2009

92. Wenbin Du, Liang Li, Kevin P. Nichols, and Rustem F. Ismagilov, "SlipChip", Lab Chip  2009 online DOI: 10.1039/b908978k pdf (593 KB) supporting information(78 KB) movieS1 (3,206 KB)

91. Weishan Liu, Hyun Jung Kim , Elena M. Lucchetta , Wenbin Du, and Rustem F. Ismagilov,"Isolation, incubation, and parallel functional testing and identification by FISH of rare microbial single-copy cells from multi-species mixtures using the combination of chemistrode and stochastic confinement", Lab Chip  2009 online DOI: 10.1039/b904958d pdf (541 KB) supporting information(205 KB)

90. Jason E. Kreutz, Liang Li, L. Spencer Roach, Takuji Hatakeyama, and Rustem F. Ismagilov, "Laterally Mobile, Functionalized Self-Assembled Monolayers at the Fluorous-Aqueous Interface in a Plug-Based Microfluidic System: Characterization and Testing with Membrane Protein Crystallization", JACS 2009 131: 6042 - 6043 pdf (528 KB) supporting information(1,043 KB)

89.Ying Liu, and Rustem F. Ismagilov, "Dynamics of Coalescence of Plugs with a Hydrophilic Wetting Layer Induced by Flow in a Microfluidic Chemistrode", Langmuir  2009 25: 2854-2859 pdf (380 KB)

88. Matthias Meier, Julia Kennedy-Darling, Se Hoon Choi, Eric M. Norstrom, Sangram S. Sisodia, and Rustem F. Ismagilov, "Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides", Angew. Chem. Int. Ed. 2009 48: 1487 - 1489 pdf (630 KB)

2008

87. Hyun Jung Kim, James Q. Boedicker, Jang Wook Choi, and Rustem F. Ismagilov, "Defined spatial structure stabilizes a synthetic multispecies bacterial community", PNAS 2008 105:18188- 18193 pdf (1,138 KB)

86. Christian J. Kastrup, James Q. Boedicker, Andrei P. Pomerantsev, Mahtab Moayeri, Yao Bian, Rebecca R. Pompano, Timothy R. Kline, Patricia Sylvestre, Feng Shen, Stephen H. Leppla, Wei-Jen Tang, and Rustem F. Ismagilov, "Spatial localization of bacteria controls coagulation of human blood by ‘quorum acting", Nature Chemical Biology 2008 4:742-750 pdf (611 KB) supporting information(2,049 KB)

85. Elena M. Lucchetta, Meghan E. Vincent, and Rustem F. Ismagilov, "A Precise Bicoid Gradient Is Nonessential during Cycles 11–13 for Precise Patterning in the Drosophila Blastoderm”, PLoS ONE. 2008 3: e3651 pdf (1,042 KB) supporting information(2,199 KB) movieS1 (102,875 KB) movieS2(31,131 KB) movieS3(14,175 KB) movieS4(28,945KB) movieS5(54,574 KB) movieS6(18,938 KB)

84. Delai Chen, Wenbin Du, Ying Liu, Weishan Liu, Andrey Kuznetsov, Felipe E. Mendez, Louis H. Philipson, and Rustem F. Ismagilov, "The chemistrode: A droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution", PNAS 2008 105: 16843-16848 pdf (1,633 KB) supporting information(4,419 KB)

83. Liang Li, Sigrid Nachtergaele, Annela M. Seddon, Valentina Tereshko, Nina Ponomarenko, and Rustem F. Ismagilov, "Simple Host-Guest Chemistry To Modulate the Process of Concentration and Crystallization of Membrane Proteins by Detergent Capture in a Microfluidic Device", JACS 2008 130: 14324-14328 pdf (1,000 KB) supporting information(9,569 KB)

82. Feng Shen, Christian J. Kastrup, Ying Liu, and Rustem F. Ismagilov, "Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries Is Controlled by Shear Rate ", Arterioscler. Thromb. Vasc. Biol. 2008 28: 2035-2041 pdf (997 KB)

81. Timothy R. Kline, Matthew K. Runyon, Mohammad Pothiawala, and Rustem F. Ismagilov, "ABO, D Blood Typing and Subtyping Using Plug-Based Microfluidics", Anal Chem 2008 80: 6190-6197 pdf (1,734 KB)

80. James Q. Boedicker, Liang Li, Timothy R. Kline, and Rustem F. Ismagilov, "Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics", Lab Chip 2008 8: 1265-1272 pdf (500 KB)

79. Rebecca R. Pompano, Hung-Wing Li, and Rustem F. Ismagilov, "Rate of mixing controls rate and outcome of autocatalytic processes—theory and microfluidic experiments with chemical reactions and blood coagulation”, Biophysical Journal 2008 95: 1531-1543 pdf (1,187 KB) supporting information(608 KB)

78. Matthew K. Runyon, Christian J. Kastrup,Bethany L. Johnson-Kerner, Thuong G, Van Ha, and Rustem F. Ismagilov, "Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations”, JACS 2008 130: 3458-3464 pdf (292 KB) supporting information(786 KB)

77. Christian J. Kastrup, Matthew K. Runyon, Elena M. Lucchetta, Jessica M. Price, and Rustem F. Ismagilov, “Using Chemistry and Microfluidics to Understand the Spatial Dynamics of Complex Biological Networks”, Acc. Chem. Res. 2008 41:449-558 pdf (2058 KB)

2007

76. Rustem F. Ismagilov; and Michel M. Maharbiz, "Can we build synthetic, multicellular systems by controlling developmental signaling in space and time?", Current Opinion in Chemical Biology 2007 11: 604-611 pdf (996 KB)

75. Rafe T. Petty; Hung-Wing Li; Jane H. Maduram; Rustem F. Ismagilov; and Milan Mrksich, "Attachment of Cells to Islands Presenting Gradients of Adhesion Ligands", J. Am. Chem. Soc. 2007 129: 8966-8967 pdf (1305 KB) supporting information(112 KB)

74. Christian J. Kastrup, and Rustem F.Ismagilov, "A physical organic mechanistic approach to understanding the complex reaction network of hemostasis (blood clotting)", J. Phys. Org. Chem. 2007 20:711-715 pdf (383 KB)

73. Christian J. Kastrup, Feng Shen, Matthew K. Runyon, and Rustem F.Ismagilov, "Characterization of the Threshold Response of Initiation of Blood Clotting to Stimulus Patch Size", Biophysical Journal 2007 93:2969-2977 pdf (1215 KB)

72. Matthew K. Runyon, Bethany L. Johnson-Kerner, Christian J. Kastrup, Thuong G. Van Ha, and Rustem F.Ismagilov, "Propagation of Blood Clotting in the Complex Biochemical Network of Hemostasis Is Described by a Simple Mechanism", JACS 2007 129: 7014-7015 pdf (93 KB) supporting information(165 KB) movie (3690 KB)

71. Christian J. Kastrup, Feng Shen, and Rustem F.Ismagilov, "Response to Shape Emerges in a Complex Biochemical Network and Its Simple Chemical Analogue", Angew. Chem. Int. Ed. 2007 46: 3660-3662 pdf (255 KB) supporting information(74 KB)

70. Liang Li, James Q. Boedicker, and Rustem F. Ismagilov, "Using a Multijunction Microfluidic Device To Inject Substrate into an Array of Preformed Plugs without Cross-Contamination: Comparing Theory and Experiments", Anal. Chem. 2007 79: 2756-2761 pdf (321 KB) supporting information(248 KB)

69. Delai L. Chen, Liang Li, Sebastian Reyes, David N. Adamson, and Rustem F. Ismagilov, "Using Three-Phase Flow of Immiscible Liquids To Prevent Coalescence of Droplets in Microfluidic Channels: Criteria To Identify the Third Liquid and Validation with Protein Crystallizations", Langmuir 2007 23: 2255-2260 pdf (175 KB)

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2006

68. Liang Li, Debarshi Mustafi, Qiang Fu, Valentina Tereshko, Delai L. Chen, Joshua D. Tice,
and Rustem F. Ismagilov, "Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins", PNAS 2006 103: 19243-19248 pdf (1.5 MB) supporting information(124 KB)

67. Cory J. Gerdts, Valentina Tereshko, Maneesh K. Yadav, Irina Dementieva, Frank Collart, Andrzej Joachimiak, Raymond C. Stevens, Peter Kuhn, Anthony Kossiakoff, and Rustem F. Ismagilov, "Time-Controlled Microfluidic Seeding in nL-Volume Droplets To Separate Nucleation and Growth Stages of Protein Crystallization ", Angew. Chem. Int. Ed. 2006 45: 8156-8160 pdf (352 KB) supporting information(332 KB)

66. Helen Song, Delai L. Chen, and Rustem F. Ismagilov, "Reactions in droplets in microfluidic channels", Angew. Chem. Int. Ed. 2006 45:7336-7356 pdf (2.33 MB)

65.Christian J. Kastrup, Matthew K. Runyon, Feng Shen, and Rustem F. Ismagilov, "Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis", PNAS 2006 103:15747-15752 pdf (1.15 MB) supporting information(143 KB)

64. David N.Adamson, Debarshi Mustafi, John X.J.Zhang, Bo Zheng and Rustem F. Ismagilov, "Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices", Lab on a Chip, 2006 6: 1178- 1186 pdf (517KB)

63. Helen Song, Hung-Wing Li, Matthew S. Munson, Thuong G. Van Ha and Rustem F. Ismagilov, "On-chip Titration of an Anticoagulant Argatroban and Determination of the Activated Partial Thromboplastin Time for Clotting within Whole Blood or Plasma Using a Plug-based Microfluidic System", Anal. Chem. 2006 78: 4839-4849 pdf (666KB) supporting information(320 KB)

62. Delai L. Chen and Rustem F. Ismagilov, "Microfluidic Cartridges Preloaded with Nanoliter Plugs of Reagents: an Alternative to 96-well Plates for Screening", COCB 2006 10: 226-231 pdf (304KB)

61. Takuji Hatakeyama, Delai L. Chen and Rustem F. Ismagilov, "Microgram-Scale Testing of Reaction Conditions in Solution Using Nanoliter Plugs in Microfluidics with Detection by MALDI-MS", J.Am.Chem.Soc. 2006 128: 2518-2519 pdf (540KB) supporting information(940 KB)

60. Elena M. Lucchetta, Matthew S. Munson and Rustem F. Ismagilov, "Characterization of the Local Temperature in Space and Time around a Developing Drosophila Embryo in a Microfluidic Device", Lab on a Chip 2006 6: 185-190 pdf (600KB)

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2005

59. Bo Zheng, Cory J Gerdts and Rustem F Ismagilov, "Using nanoliter plugs in microfluidics to facilitate and understand protein crystallization", Current Opinion in Structural Biology 2005 15: 548–555 pdf (468 KB)

58. Maneesh K. Yadav, Cory J. Gerdts, Ruslan Sanishvili, Ward W. Smith, L. Spencer Roach, Rustem F. Ismagilov, Peter Kuhn and Raymond C. Stevens, "In Situ Data Collection and Structure Refinement from Microcapillary Protein Crystallization", Journal of Applied Crystallography 2005 38: 900-905 pdf (352 KB)

57. Delai L. Chen, Cory J. Gerdts, and Rustem F. Ismagilov, "Using Microfluidics to Observe the Effect of Mixing on Nucleation of Protein Crystals", J. Am. Chem. Soc. 2005 127: 9672-9673 pdf (106 KB) supporting information(124 KB)

56. Jing Su, Michelle R. Bringer, Rustem F. Ismagilov, and Milan Mrksich,  "Combining Microfluidic Networks and Peptide Arrays for Multi-Enzyme Assays", J. Am. Chem. Soc. 2005 127: 7280-7281 pdf (100 KB)

55. Elena M. Lucchetta, Ji Hwan Lee, Lydia A. Fu, Nipam H. Patel, and Rustem F. Ismagilov,  "Dynamics of Drosophila Embryonic Patterning Network Perturbed in Space and Time with Microfluidics", Nature 2005 434: 1134-1138   pdf (318 KB)  supporting information (727 KB)

54. Bo Zheng and Rustem F. Ismagilov,  "A Microfluidic Approach for Screening Submicroliter Volumes Against Multiple Reagents by Using Preformed Arrays of Nanoliter Plugs in a Three-Phase Liquid/Liquid/Gas Flow", Angew. Chem. Int. Ed. 2005 44 (17): 2520-2523 pdf (208 KB) supporting information(48 KB)

53. L. Spencer Roach, Helen Song, and Rustem F. Ismagilov,  "Controlling Nonspecific Protein Adsorption in a Plug-Based Microfluidic System by Controlling Interfacial Chemistry Using Fluorous-Phase Surfactants", Anal. Chem. 2005 77 (3): 785-796   pdf (545 KB) supporting information(627 KB)

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2004

52. Bo Zheng, Joshua D. Tice, and Rustem F. Ismagilov,  "Formation of Arrayed Droplets by Soft Lithography and Two-Phase Fluid Flow, and Application in Protein Crystallization", Adv. Mater. 2004 16:1365-1368   pdf (168 KB)

51. Bo Zheng, Joshua D. Tice, and Rustem F. Ismagilov,  "Formation of Droplets of Alternating Composition in Microfluidic Channels and Applications to Indexing of Concentrations in Droplet-Based Assays", Anal. Chem. 2004 76: 4977-4982   pdf (302 KB)

50. Ilya A. Shestopalov, Joshua D. Tice, and Rustem F. Ismagilov,  "Multi-Step Synthesis of Nanoparticles Performed on Millisecond Time Scale in a Microfluidic Droplet-Based System", Lab on a Chip 2004 4: 316-321   pdf (1,027 KB)

49. Cory J. Gerdts, David E. Sharoyan, and Rustem F. Ismagilov,  "A Synthetic Reaction Network: Chemical Amplification Using Nonequilibrium Autocatalytic Reactions Coupled in Time", J. Am. Chem. Soc. 2004 126: 6327-6331  pdf (154 KB)

48. Bo Zheng, Joshua D. Tice, L. Spencer Roach, and Rustem F. Ismagilov,  "A Droplet-Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor-Diffusion Methods with On-Chip X-Ray Diffraction", Angew. Chem. Int. Edit. 2004 43: 2508-2511  pdf (534 KB) supporting information(121 KB)

47. Michelle R. Bringer, Cory J. Gerdts, Helen Song, Joshua D. Tice, and Rustem F. Ismagilov,  "Microfluidic Systems for Chemical Kinetics that Rely on Chaotic Mixing in Droplets", Philos. T. Roy. Soc. A 2004 362: 1087-1104  pdf (966 KB)

46. Matthew K. Runyon, Bethany L. Johnson-Kerner, and Rustem F. Ismagilov,  "Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System", Angew. Chem. Int. Edit. 2004 43: 1531-1536  pdf (171KB)

45. Joshua D. Tice, Adam D. Lyon, and Rustem F. Ismagilov,  "Effect of Viscosity on Droplet Formation and Mixing in Microfluidic Channels", Anal. Chim. Acta 2004 507: 73-77  pdf (228 KB)

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2003

44. Helen Song, Michelle R. Bringer, Joshua D. Tice, Cory J. Gerdts, and Rustem F. Ismagilov,  "Experimental Test of Scaling of Mixing by Chaotic Advection in Droplets Moving Through Microfluidic Channels", Appl. Phys. Lett. 2003 83: 4664-4666   pdf (168 KB)

43. Helen Song and Rustem F. Ismagilov,  "Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents",  J. Am. Chem. Soc. 2003 125: 14613-14619  pdf (277 KB)

42. Rustem F. Ismagilov,  "Integrated Microfluidic Systems", Angew. Chem. Int. Edit. 2003 42: 4130-4132   pdf (132 KB)

41. Joshua D. Tice, Helen Song, Adam D. Lyon, and Rustem F. Ismagilov,  "Formation of Droplets and Mixing in Multiphase Microfludics at Low Values of the Reynolds and the Capillary Numbers",  Langmuir. 2003 19 (22) 9127-9133  pdf (462 KB)

40. Bo Zheng, L. Spencer Roach, and Rustem F. Ismagilov, "Screening of Protein Crystallization Conditions on a Microfluidic Chip Using Nanoliter-Size Droplets",  J. Am. Chem. Soc. 2003 125 (37): 11170-11171   pdf (156 KB)

39. Helen Song, Joshua D. Tice, and Rustem F. Ismagilov,  "A Microfluidic System for Controlling Reaction Networks in Time", Angew. Chem. Int. Edit. 2003 42 (7): 768-772   pdf (315 KB)

The reprints of articles are provided for personal and educational use only, and are subject to the copyright by their respective publishers.

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Complete List   

Microfluidics

1. Ismagilov, R. F.; Rosmarin, D.; Kenis, P. J. A.; Chiu, D. T.; Zhang, W.; Stone, H. A.; Whitesides, G. M. "Pressure-driven laminar flow in tangential microchannels: an elastomeric microfluidic switch", Anal. Chem. 2001, 73, 4682-4687.

2. Ismagilov, R. F.; Ng, J. M. K.; Kenis, P. J. A.; Whitesides, G. M. "Microfluidic arrays of fluid-fluid diffusional contacts as detection elements and combinatorial tools", Anal. Chem. 2001, 73, 5207-5213.

3. Kenis, P. J. A.; Ismagilov, R. F.; Takayama, S.; Whitesides, G. M.; Li, S. L.; White, H. S. "Fabrication inside microchannels using fluid flow", Accounts Chem. Res. 2000, 33, 841-847.

4. Ismagilov, R. F.; Stroock, A. D.; Kenis, P. J. A.; Whitesides, G.; Stone, H. A. "Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels", Appl. Phys. Lett. 2000, 76, 2376-2378.

5. Takayama, S.; McDonald, J. C.; Ostuni, E.; Liang, M. N.; Kenis, P. J. A.; Ismagilov, R. F.; Whitesides, G. M. "Patterning cells and their environments using multiple laminar fluid flows in capillary networks", Proc. Natl. Acad. Sci. U. S. A. 1999, 96, 5545-5548.

6. Kenis, P. J. A.; Ismagilov, R. F.; Whitesides, G. M. "Microfabrication inside capillaries using multiphase laminar flow patterning", Science 1999, 285, 83-85.
   

Complexity

1. Ismagilov, R. F.; Schwartz, A.; Bowden, N.; Whitesides, G. M. "Autonomous movement and self-assembly", Angew. Chem.-Int. Edit. 2002, 41, 652.

2. Ismagilov, R. F.; Rosmarin, D.; Gracias, D. H.; Stroock, A. D.; Whitesides, G. M. "Competition of intrinsic and topographically imposed patterns in Benard-Marangoni convection", Appl. Phys. Lett. 2001, 79, 439-441.

3. Whitesides, G. M.; Ismagilov, R. F. "Complexity in chemistry", Science 1999, 284, 89-92.

Materials and Electron Transfer

1. Holmlin, R. E.; Ismagilov, R. F.; Haag, R.; Mujica, V.; Ratner, M. A.; Rampi, M. A.; Whitesides, G. M. "Correlating electron transport and molecular structure in organic thin films", Angew. Chem.-Int. Edit. 2001, 40, 2316-+.

2. Nelsen, S. F.; Ismagilov, R. F.; Gentile, K. E.; Powell, D. R. "Temperature effects on electron transfer within intervalence bis(hydrazine) radical cations", J. Am. Chem. Soc. 1999, 121, 7108-7114.

3. Nelsen, S. F.; Ismagilov, R. F. "Ion pairing effects on bis(hydrazine) intervalence radical cations", J. Phys. Chem. A 1999, 103, 5373-5378.

4. Ismagilov, R. F. "Mathematical description of kinetic resolution with an enantiomerically impure catalyst and nonracemic substrate", J. Org. Chem. 1998, 63, 3772-3774.
    

5. Nelsen, S. F.; Ismagilov, R. F.; Powell, D. R. "Effects of bridge redox state levels on the electron transfer and optical properties of intervalence compounds with hydrazine charge-bearing units", J. Am. Chem. Soc. 1998, 120, 1924-1925.

6. Nelsen, S. F.; Ismagilov, R. F.; Teki, Y. "Comparison of the singlet, triplet energy gap of a symmetrical diradical dication with ET parameters derived from its optical spectrum", J. Am. Chem. Soc. 1998, 120, 2200-2201.

7. Nelsen, S. F.; Ismagilov, R. F.; Gentile, K. E.; Nagy, M. A.; Tran, H. Q.; Qu, Q. L.; Halfen, D. T.; Odegard, A. L.; Pladziewicz, J. R. "Indirect determination of self-exchange electron transfer rate constants", J. Am. Chem. Soc. 1998, 120, 8230-8240.

8. Nelsen, S. F.; Ismagilov, R. F.; Trieber, D. A. "Adiabatic electron transfer: Comparison of modified theory with experiment", Science 1997, 278, 846-849.
   

9. Nelsen, S. F.; Ismagilov, R. F.; Powell, D. R. "Charge-localized p-phenylenedihydrazine radical cations: ESR and optical studies of intramolecular electron transfer rates", J. Am. Chem. Soc. 1997, 119, 10213-10222.

10. Nelsen, S. F.; Ramm, M. T.; Ismagilov, R. F.; Nagy, M. A.; Trieber, D. A.; Powell, D. R.; Chen, X.; Gengler, J. J.; Qu, Q. L.; Brandt, J. L.; Pladziewicz, J. R. "Estimation of self-exchange electron transfer rate constants for organic compounds from stopped-flow studies", J. Am. Chem. Soc. 1997, 119, 5900-5907.
    

11. Nelsen, S. F.; Ismagilov, R. F.; Chen, L. J.; Brandt, J. L.; Chen, X.; Pladziewicz, J. R. "Slow electron transfer reactions involving tetraisopropylhydrazine", J. Am. Chem. Soc. 1996, 118, 1555-1556.
    

12. Nelsen, S. F.; Ismagilov, R. F.; Powell, D. R. "Charge localization in a dihydrazine analogue of tetramethyl-p- phenylenediamine radical cation", J. Am. Chem. Soc. 1996, 118, 6313-6314.