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Contact Information:
Office: CIS E305 Email: r-ismagilov@uchicago.edu Voice: 773 702 5816 Fax: 773 834 3544 Mailing Address: 929 East 57th Street, Chicago, IL 60637 Directions
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Graduate positions available: Fully funded positions are available for PhD students in the lab of Prof. Rustem Ismagilov at the University of Chicago, in the Biophysical Sciences or Chemistry graduate programs. We use microfluidics to understand complex systems, and develop tools for research and medicine. Recent projects include 1) development of “chemistrode? a microfluidic device for to deliver, record, and analyze chemical information from cells and tissues; 2) understanding general principles that govern biological dynamics in space and time; 3) using chemistrode and other microfluidic tools to understand biological dynamics and signaling in vivo and in culture; 4) synthetic biology to construct microbial communities; 5) developing technologies for control of crystallization and aggregation of proteins in nanoliter volumes; 6) determining the mechanisms that maintain robustness of early patterning of the Drosophila embryo; 7) understanding how in blood coagulation simple dynamics arises from complexity; and 8) developing new catalysts using genetic algorithms. See http://ismagilovlab.uchicago.edu/publications.html for details. Interests of current lab members span microfluidics, analytical chemistry, organic and physical chemistry, catalysis, biophysics, biochemistry, single-molecule microscopy, microbiology, developmental biology, Alzheimer's, diabetes, and immunology. We welcome candidates from all disciplines, including chemistry, biology, engineering, or physics. Interested applicants should apply to the University of Chicago Chemistry graduate program (http://chemistry.uchicago.edu/phdapp.shtml) or University of Chicago Biophysical Sciences graduate program (http://biophysics.uchicago.edu/students/application.html) and mention the Ismagilov group on the application. Contact ismagilovlab@uchicago.edu with questions.
POSTDOCTORAL: We welcome postdoctoral applications from talented, motivated individuals. For ongoing projects see the list of publications and the archive of current and past positions below.
Clinical diagnostics with microfluidics A postdoctoral position is available to join a cutting-edge research project that focuses on developing microfluidic technology to address problems in clinical diagnostics.
The candidate should have an extensive hands-on experience in molecular biology and/or clinical chemistry, ideally in the assay development context, should have thorough understanding the current state of the art technique in molecular biology and clinical chemistry and their limitations in the field of clinical diagnostics. Ideal candidate has clinical assay development experience or other demonstrable experiences leading to understanding of the process of clinical assay development, including state of the art of current technologies, unmet needs, limitations of current techniques, and potential pitfalls of the assay development process.
Intimate experience with developing and troubleshooting protocols for molecular biological techniques, for example PCR and immunoassays, required. Understanding of the limitations of these techniques and their applications to address specific medical problems strongly preferred. Previous experience in clinical chemistry or in research and development strongly preferred. Scientific, peer-reviewed publications or extensive documented experience in clinical assay development is strongly preferred.
A resume, a brief research statement explaining how applicant’s expertise could advance these projects, and reference contact information are required to be considered for this position.
Microbial Communities with Microfluidics These NIH-funded projects focus on microfluidic technology to develop new culturing and screening technologies, to understand metabolic and signaling interactions among microbes in microbial communities and between microbes and host cells, including the effects of microenvironment on virulence. Strong experience in experimental microbiology is required. Strong leadership and communication skills are desirable. Experience in microfluidics is not required. Respond to ismagilovlab@uchicago.edu with a CV and a brief statement describing your expertise, interests, and potential contributions.
Complexity in general A postdoctoral position is available to use microfluidics and chemistry to determine the underlying mechanisms by which complex biological networks operate (results for the blood clotting network were reported in Angew Chemie 2004 43:1531, and PNAS 2006 103: 15747, and for Drosophila in Nature 2005 434: 1134). The ideal candidate would be highly motivated, have a strong publication record, and have prior expertise in micro/nanotechnology, chemical biology, or complex systems biology.
Crystallization and structural analysis of proteins in microcapillaries This project aims to develop technologies for crystallization and structural analysis of proteins in nanoliter volumes. The work will be carried out in collaboration with groups of other members (Lance Stewart, deCODE biostructures, Ray Stevens and Peter Kuhn, Scripps) of the ATCG3D center (http://www.atcg3d.org/). Experience in expression, purification, crystallization, and structural analysis of macromolecules is essential. Strong leadership skills, communication skills, and interest in technology development are highly desirable.
Microfluidic crystallization of membrane proteins This project aims to develop microfluidic technologies to enable crystallization of membrane proteins in nanoliter volumes inside microcapillaries. The work will require interactions with the ATCG3D center (http://www.atcg3d.org/ -- Lance Stewart, deCODE biostructures, PI) and JCIMPT center (http://jcimpt.scripps.edu/ -- Ray Stevens and Peter Kuhn), and solid communication skills will be important for candidates. Experience in expression, purification, crystallization, and structural analysis of membrane proteins is highly desirable. Candidates with strong interest in interdisciplinary research and in technology development will be preferred. Experience in microfluidics is not required.
Study robustness of development in Drosophila using microfluidics NIH-funded postdoctoral position is available to use microfluidics to determine the mechanism that maintains robustness of early patterning of the Drosophila embryo (initial results reported in Nature 2005 434: 1134-1138). Expertise in Drosophila developmental biology is required. The ideal candidate would be highly motivated, interdisciplinary, and seeking to learn microfluidic technology.
Use C.elegans and microfluidics to understand complex networks A postdoctoral position is available, in collaboration with the Morimoto lab, to use C. elegans and microfluidics to study protein aggregation. Expertise in C. elegans biology is required and experience creating transgenic animals is desirable. The ideal candidate would be highly motivated, interdisciplinary, and seeking to learn microfluidic technology.
UNDERGRADUATE STUDENTS: Check for updates!
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